--- title: "Supplement of the week: Designs for Health L-5-MTHF" description: L-5-MTHF supplements provide a natural, biologically active form of folate. image: https://blog.primohealth.com/hs-fs/file-2014758915-jpg/images/l-5_mthf-resized-600.jpg --- [![Primo Health - Daniel Sanelli](https://blog.primohealth.com/hs-fs/hubfs/PHC_LogoCR_HUBSPOT.png?width=400&height=154&name=PHC_LogoCR_HUBSPOT.png "Primo Health - Daniel Sanelli")](https://www.primohealth.com) - [About](https://www.primohealth.com/about-daniel-sanelli) - [Program](https://www.primohealth.com/functional-blood-chemistry-analysis) - [Store](https://www.primohealth.com/primo-health-store) - [How to Shop](https://www.primohealth.com/primo-health-store) - [Primo Health Store](https://primohealthcoach.gethealthy.store) - [FullScript Dispensary](https://us.fullscript.com//welcome/primohealth) - [Apex Energetics Store](https://www.myhcpstore.com/) - [Blog](https://blog.primohealth.com) - [Contact](https://www.primohealth.com/contact-daniel-sanelli) [Back to blog](https://blog.primohealth.com) # Supplement of the week: Designs for Health L-5-MTHF ![Picture of Daniel Sanelli, M.Sc.](https://app.hubspot.com/settings/avatar/18cc72d6b6902b69f00313c2a3004f25) [Daniel Sanelli, M.Sc.](https://blog.primohealth.com/author/daniel-sanelli-m-sc) Nov 3, 2014 4:00:00 PM [emotional health](https://blog.primohealth.com/topic/emotional-health) [smart supplementation](https://blog.primohealth.com/topic/smart-supplementation) ### **![L-5 MTHF](https://blog.primohealth.com/hs-fs/file-2014758915-jpg/images/l-5_mthf-resized-600.jpg)Quick Overview** L-5-MTHF provides a natural, biologically active form of folate. Folate is essential for cell division and growth, and also works to balance the homocysteine pathway. This formula provides a generous 5 mg per capsule of folate in the bioidentical, bioactive form, 5-methyltetrahydrofolate. L-5-MTHF (the “L” signifying that it is the all-natural \[6S\] isomer) is the active circulating form of folate found in the body and one of the several forms found in food. In nature it is found only as this \[6S\] isomer, which is why DFH uses L-5-MTHF, the natural isomer, rather than the mixed (or racemic) form. Our L-5-MTHF uses the **patented folate derivative Quatrefolic®**. This innovative form of folate has demonstrated high bioavailability and solubility as well as long lasting stability. Quatrefolic® L-5-MTHF helps to increase blood folate levels much better than folic acid. ### **Product Description** Folate (as Quatrefolic® \[6S\]-5-methyltetrahydrofolate,glucosamine salt 10 mg) 5 mg
 **High dose, 5 mg methylated folate, as the all natural 6S isomer

** **L-5-MTHF** is a safe and effective way to increase the body’s folate levels. It is especially helpful for patients with demonstrated increased need for folate such as those with either the A1298C or C677T MTHFR mutation. **

L-5-MTHF 5 mg should be considered when high doses of folate are needed**.
 Individuals who have tested homozygous with either the A1298C or C677T MTHFR mutation, or those with elevated homocysteine levels, should be using L-5-MTHF as the preferred form of folate supplementation. This will be more effective for them than other forms of folic acid or folates. **Others who may benefit from L-5-MTHF**:
 Pregnant women and women wishing to become pregnant who have familial history of depression, high homocysteine levels, or genetic defect in MTHFR. Note: All pregnant women should consider taking **Prenatal Pro™** as their comprehensive multivitamin; can combine with **L-5-MTHF** if higher levels of folate are needed. Women with abnormal pap smears (precancerous) Those with very high homocysteine levels not responding quickly to **Homocysteine Supreme™**(consider using them together) Dialysis patients Organic acid testing that reveals elevated FIGLU (marker used to identify folate deficiency) Patients with family history of dementia/vascular dementia
 Patients with depression Long-term alcoholism Long-term use of oral contraceptives, and persistent use of medications to lower folate levels, including high doses of NSAIDs such as aspirin or ibuprofen; anticonvulsants (phenytoin, phenobarbital, and primidone); trimethoprim (antibiotic), pyrimethamine (antimalarial), triamterene (blood pressure med.) and sulfasalazine (treatment for ulcerative colitis). Do not take 5-MTHF simultaneously with the cholesterol-lowering agents cholestyramine or colestipol because they may decrease the absorption of folate. ### **Dosage** As a dietary supplement, take one capsule daily or as directed by your health care practitioner. [![Buy L-5-MTHF Now!](https://no-cache.hubspot.com/cta/default/100332/88985669-3c74-459e-b8fa-725e4cf3ebc2.png)](https://cta-redirect.hubspot.com/cta/redirect/100332/88985669-3c74-459e-b8fa-725e4cf3ebc2) View Comments Hide Comments [Share this blog post on Twitter](https://twitter.com/intent/tweet?text=I+found+this+interesting+blog+post&url=https://blog.primohealth.com/bid/186450/Supplement-of-the-week-Designs-for-Health-L-5-MTHF) [Share this blog post on Facebook](http://www.facebook.com/share.php?u=https://blog.primohealth.com/bid/186450/Supplement-of-the-week-Designs-for-Health-L-5-MTHF) [Share this blog post on LinkedIn](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.primohealth.com/bid/186450/Supplement-of-the-week-Designs-for-Health-L-5-MTHF) ## Related Articles ## [Supplement of the week: Designs for Health B-Supreme](https://blog.primohealth.com/bid/186611/Supplement-of-the-week-Designs-for-Health-B-Supreme) ![Picture of Daniel Sanelli, M.Sc.](https://app.hubspot.com/settings/avatar/18cc72d6b6902b69f00313c2a3004f25) [Daniel Sanelli, M.Sc.](https://blog.primohealth.com/author/daniel-sanelli-m-sc) Nov 17, 2014 2:00:00 PM ![Supplement of the week: Designs for Health B-Supreme](https://blog.primohealth.com/hs-fs/file-2165083369-jpg/images/bsp120-lrg-resized-600.jpg) [smart supplementation](https://blog.primohealth.com/topic/smart-supplementation) ### **Quick Overview** This very powerful B vitamin combination formula supplies most of the B vitamins in their coenzymated forms so the body does not have to phosphorylate... [Read More](https://blog.primohealth.com/bid/186611/Supplement-of-the-week-Designs-for-Health-B-Supreme) 0 Comments ## [Health Benefits Of Vitamin B12](https://blog.primohealth.com/bid/78054/Health-Benefits-Of-Vitamin-B12) ![Picture of Daniel Sanelli, M.Sc.](https://app.hubspot.com/settings/avatar/18cc72d6b6902b69f00313c2a3004f25) [Daniel Sanelli, M.Sc.](https://blog.primohealth.com/author/daniel-sanelli-m-sc) Jul 7, 2011 8:00:00 AM ![Health Benefits Of Vitamin B12](https://blog.primohealth.com/hs-fs/file-16134244-jpg/images/vitamin-b12-benefits-resized-600.jpg) [smart supplementation](https://blog.primohealth.com/topic/smart-supplementation) #### Cobalamin, also known as Vitamin B12, has a bright red color and has a high content of cobalt. It is one of the many B Vitamins, and it is essential to life. Vitamin... [Read More](https://blog.primohealth.com/bid/78054/Health-Benefits-Of-Vitamin-B12) 0 Comments [![Primo Health - Daniel Sanelli](https://blog.primohealth.com/hs-fs/hubfs/PHC_LogoCR_HUBSPOT.png?width=400&height=154&name=PHC_LogoCR_HUBSPOT.png "Primo Health - Daniel Sanelli")](http://primohealth.com) Follow us on Facebook Follow us on LinkedIn Follow us on Twitter Follow us on Instagram --- Copyright © 2026, Primo Health Privacy Policy  |  Terms of Use