--- title: The Natural Appetite Suppressant CCK description: Cholecystokinin (CCK) is a very interesting neuropeptide that has a great benefit to anyone who is trying to lose weight. image: https://blog.primohealth.com/hs-fs/file-2243233344-jpg/images/natural-appetite-suppressant-resized-600.jpg --- [![Primo Health - Daniel Sanelli](https://blog.primohealth.com/hs-fs/hubfs/PHC_LogoCR_HUBSPOT.png?width=400&height=154&name=PHC_LogoCR_HUBSPOT.png "Primo Health - Daniel Sanelli")](https://www.primohealth.com) - [About](https://www.primohealth.com/about-daniel-sanelli) - [Program](https://www.primohealth.com/functional-blood-chemistry-analysis) - [Store](https://www.primohealth.com/primo-health-store) - [How to Shop](https://www.primohealth.com/primo-health-store) - [Primo Health Store](https://primohealthcoach.gethealthy.store) - [FullScript Dispensary](https://us.fullscript.com//welcome/primohealth) - [Apex Energetics Store](https://www.myhcpstore.com/) - [Blog](https://blog.primohealth.com) - [Contact](https://www.primohealth.com/contact-daniel-sanelli) [Back to blog](https://blog.primohealth.com) # The Natural Appetite Suppressant CCK ![Picture of Daniel Sanelli, M.Sc.](https://app.hubspot.com/settings/avatar/18cc72d6b6902b69f00313c2a3004f25) [Daniel Sanelli, M.Sc.](https://blog.primohealth.com/author/daniel-sanelli-m-sc) Dec 8, 2014 10:00:00 AM [brain health](https://blog.primohealth.com/topic/brain-health) [weight management](https://blog.primohealth.com/topic/weight-management) [smart supplementation](https://blog.primohealth.com/topic/smart-supplementation) [digestive health](https://blog.primohealth.com/topic/digestive-health) ### *CCK: The Natural Appetite Suppressant* By Gene Bruno, MS, MHS – Dean of Academics, Huntington College of Health Sciences ![natural_appetite_supresant](https://blog.primohealth.com/hs-fs/file-2243233344-jpg/images/natural-appetite-suppressant-resized-600.jpg?width=215&height=340&name=natural-appetite-suppressant-resized-600.jpg) Cholecystokinin (CCK) is a very interesting neuropeptide that has a great benefit to anyone who is trying to lose weight. CCK is produced by special cells in the intestinal wall in response to a meal that contains some fat. Basically, it causes bile and pancreatic enzymes to be released for fat digestion. Besides helping fat digestion, research has demonstrated that CCK also causes a reduction in food intake in several species, including humans.1 In other words, it helps you to control your appetite; clearly an advantage if your trying to eat less and reduce body fat. ### **How it works** There seems to a few mechanisms by which this takes place. One is related to CCK’s role in digestion: it slows down intestinal motility; that is, it causes food to move more slowly through the intestines, which gives you the sensation of being full for a longer period of time. Another mechanism is that CCK modulates dopaminergic neurotransmission in the brain. This is similar to the way the prescription weight loss drug Phentermine works: by increasing the level of dopamine in the brain, which increases metabolism and decreases hunger. [![Learn about Designs for Health Weight Management Products Now!](https://no-cache.hubspot.com/cta/default/100332/1cb5d27e-363c-4176-b9ca-f50c8d9446e4.png)](https://cta-redirect.hubspot.com/cta/redirect/100332/1cb5d27e-363c-4176-b9ca-f50c8d9446e4) Yet another mechanism seems to be CCK’s relationship to glucagon. Glucagon is a pancreas hormone whose primary function it is to help raise blood sugar levels, thereby helping to stabilize appetite. Animal research indicates that CCK works synergistically with glucagon to improve satiety (satisfied feelings of fullness) and reduce feeding time.2 ![enjoy_your_meal](https://blog.primohealth.com/hs-fs/file-2243233354-jpg/images/scale001-resized-600.jpg?width=216&height=162&name=scale001-resized-600.jpg) ### **Enjoy your meal** One of the really great things revealed in CCK research is that this neuropeptide can decrease meal size in a specific, dose-related manner, without signs of acute toxicity (as is often seen in prescription anorectic drugs) and without decreasing the reported pleasure or satisfaction of the meal.3 ### **Break down fat** Another interesting fact about CCK is that it stimulates lipolysis (fat breakdown) in adipose tissue. This seems to happen by a mechanism that is independent of its appetite suppressing properties. The importance of this function was demonstrated in a study where women using oral contraceptives experienced reduced serum levels of CCK, which was correlated to an increase in body fat. Although the amount of CCK released as a result of eating a meal was unaffected, serum (blood) CCK was reduced while serum fats and sugar increased.4 Naturally, these extra calories were just stored as body fat. Clearly, CCK plays important roles in body composition as well as appetite control. Anyone, trying to reduce body fat might seriously consider integrating it into their supplementation program. [![choosing-supplements-handout-download](https://no-cache.hubspot.com/cta/default/100332/b84dcc62-0850-4a81-bbc2-1794d6259b4d.png)](https://cta-redirect.hubspot.com/cta/redirect/100332/b84dcc62-0850-4a81-bbc2-1794d6259b4d) *Smart Supplementation™ is a free series of educational literature created by Huntington College of Health Sciences (HCHS) as a public service. Although copyrighted, it may be freely photocopied and distributed, but may not be altered in any way. Smart Supplementation™ is not intended as medical advice. For diagnosis and treatment of any medical condition, consult your physician.* ### **Reference** 1.Lieverse, R., et al, Biol Psychiatry (1995) 37 (5): 331-5. 
2.    Le Sauter, J. and N. Geary, J Physiol (1987) 253 (5): Pt 2. 
3.    Smith, G. and J. Gibbs, Am J Clin Nutr; (1992) 55 (1 Suppl): 283S-285S 
4.    Hirschberg, A., et al, Contraception (1996) 53 (2):109-13. View Comments Hide Comments [Share this blog post on Twitter](https://twitter.com/intent/tweet?text=I+found+this+interesting+blog+post&url=https://blog.primohealth.com/bid/186806/The-Natural-Appetite-Suppressant-CCK) [Share this blog post on Facebook](http://www.facebook.com/share.php?u=https://blog.primohealth.com/bid/186806/The-Natural-Appetite-Suppressant-CCK) [Share this blog post on LinkedIn](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.primohealth.com/bid/186806/The-Natural-Appetite-Suppressant-CCK) ## Related Articles ## [Natural Breast Enlargement](https://blog.primohealth.com/bid/186432/Natural-Breast-Enlargement) ![Picture of Daniel Sanelli, M.Sc.](https://app.hubspot.com/settings/avatar/18cc72d6b6902b69f00313c2a3004f25) [Daniel Sanelli, M.Sc.](https://blog.primohealth.com/author/daniel-sanelli-m-sc) Nov 3, 2014 11:00:00 AM ![Natural Breast Enlargement](https://blog.primohealth.com/hs-fs/file-1995068500-jpg/images/illustration_trigonella_foenum-graecum0_clean-resized-600.jpg) [herbs & botanicals](https://blog.primohealth.com/topic/herbs-botanicals) [female health](https://blog.primohealth.com/topic/female-health) [endocrine health](https://blog.primohealth.com/topic/endocrine-health) [smart supplementation](https://blog.primohealth.com/topic/smart-supplementation) *Breast Enlargement Botanicals* By Gene Bruno, MS, MHS – Dean of Academics, Huntington College of Health Sciences Nowadays, many women who desire larger breasts are... [Read More](https://blog.primohealth.com/bid/186432/Natural-Breast-Enlargement) 0 Comments ## [Nutrition Tips for Cellulite Reduction](https://blog.primohealth.com/bid/186554/Nutrition-Tips-for-Cellulite-Reduction) ![Picture of Daniel Sanelli, M.Sc.](https://app.hubspot.com/settings/avatar/18cc72d6b6902b69f00313c2a3004f25) [Daniel Sanelli, M.Sc.](https://blog.primohealth.com/author/daniel-sanelli-m-sc) Nov 12, 2014 10:00:00 AM ![Nutrition Tips for Cellulite Reduction](https://blog.primohealth.com/hs-fs/file-2165082794-jpg/images/cellulite_reduction-resized-600.jpg) [herbs & botanicals](https://blog.primohealth.com/topic/herbs-botanicals) [female health](https://blog.primohealth.com/topic/female-health) [skin health](https://blog.primohealth.com/topic/skin-health) [sports nutrition](https://blog.primohealth.com/topic/sports-nutrition) [smart supplementation](https://blog.primohealth.com/topic/smart-supplementation) ### *Cellulite Reduction* By Gene Bruno, MS, MHS – Dean of Academics, Huntington College of Health Sciences Cellulite is more common in women than in men. The reason for this... [Read More](https://blog.primohealth.com/bid/186554/Nutrition-Tips-for-Cellulite-Reduction) 0 Comments [![Primo Health - Daniel Sanelli](https://blog.primohealth.com/hs-fs/hubfs/PHC_LogoCR_HUBSPOT.png?width=400&height=154&name=PHC_LogoCR_HUBSPOT.png "Primo Health - Daniel Sanelli")](http://primohealth.com) Follow us on Facebook Follow us on LinkedIn Follow us on Twitter Follow us on Instagram --- Copyright © 2026, Primo Health Privacy Policy  |  Terms of Use